What is Acetarsol?

Acetarsol is a substance derived from arsenic. However, although arsenic is a poison, it has been found to be very effective in cases of resistant proctitis.

Is it safe?

Acetarsol has proved safe and effective in clearly defined doses. Some cases of poisoning have occurred with prolonged courses (greater than 4 years in both cases) or with large doses (3.5-7.9 g). Levels in the blood and urine may be initially high but rapidly fall (usually after 1 week) as the lining of the rectum heals. When treatment is stopped there should be no further trace of the drug after approximately 4 weeks.

Indications for use

This treatment is usually only prescribed when the standard treatments for colitis, (mesalazine or steroids) have failed to settle the symptoms.

Dosage & administration

The treatment should be prescribed by your specialist and taken according to instructions. Suppositories will usually be prescribed as 250 mg morning and evening, for up to 1 month. The suppositories should be lubricated with a little K Y jelly or water and then inserted into the back passage.

Are there any side effects?

Acetarsol is generally safe to use if taken correctly according to your doctor’s instructions. Possible side effects may occur and would be related to arsenic toxicity.